Abstract

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF SCHIFF’s BASE OXINDOLE DERIVATIVES OF NORFLOXACIN NMANNICH BASES

Ravindra Karande*, Anuradha Choudhari and Sandhya Gawai

Abstract

Background: A Schiff base, a pharmacologically privileged scaffold is a nitrogen analog of an aldehyde or ketone in which the Carbonyl (C=O) group is replaced by Imine (C=N-R) group. Mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, an aldehyde and a carbon acid. Objective: The goal of the study is to synthesize combined form of the various Schiff’s bases of Oxindole with Fluoro-quinolone antibiotic like Norfloxacin for enhanced Pharmacological and biological activity. Methods: Various conventional as well as green (Microwave) methods are incorporated for synthesis of Schiff’s bases as well as Mannich bases on comparative background. Biological evaluation was done according to the literature. Results and conclusion: Despite of Norfloxacin’s versatile pharmacological activities, it possesses certain functional groups in it, which on metabolism decreases bioavailability of the drug as well as increases adverse effects. Thus, Derivatization method was incorporated to shun the side effects of the drug by synthesizing its Mannich bases with Schiff bases having additional antibacterial activity.

Keywords: Schiff’s Base, Mannich Base, Oxindole, Norfloxacin, antibacterial, Microwave etc.