Abstract

NEW LC–UV METHODS FOR PHARMACEUTICAL ANALYSIS OF NOVEL BRONCHODILATOR DOXOFYLLINE AND ANTIDEPRESSANT SERTRALINE COMBINATION METHOD IN DIFFERENT DOSAGE FORM LIKE TABLET CAPSULE AND SUSPENSION AND INJECTION

P. Kajal*, Dr. P. Arun, P. Shailendra, P. Bhavesh, D. Neelesh and V. Koushal

Abstract

A sensitive & selective stability indicting RP-HPLC method has been developed & validated for the analysis of Sertraline & Doxofylline in table, sustained release (capsule) and syrup and injection and suspension dosage form. Based on peak purity results, obtained from the analysis of samples using described method, it can be concluded that the absence of co-eluting peak along with the main peak of Sertraline & Doxofylline indicated that the developed method is specific for the estimation of Sertraline & Doxofylline. Further the proposed RP-HPLC method has excellent sensitivity, precision and reproducibility.

Keywords: Qualitative analysis, sertraline, doxofylline, chromatography, validation, tablet, capsule, injection suspension.