Abstract

TOXICITY STUDIES OF HYDRO ALCOHOLIC EXTRACTS OF FICUS GIBBOSA LINN. LEAVES AND STEM BARK IN RATS

Dr. Sanjaya Kumar Y. R.*, Dr. Thamizh Selvam N., Mr. Vasanthakumar K. G., Dr. Deep V. C., Dr. Sudesh N. Gaidhani, Smt. Divya A. and Dr. Swamy G. K.

Abstract

Hydro alcoholic extracts of Ficus gibbosa Linn. (leaves and stem bark ) were assessed for acute toxicity and 28 days repeated oral toxicity in Sprague Dawley (SD) rats through OECD guidelines. The test drug up to dose of 2000 mg /Kg B.W did not cause any death and clinical signs of toxicity in female SD rats during acute toxicity study. Animals which received the test extracts consecutively for a period of 28 days survived throughout the period of study and no signs of toxicity were seen as evident by hematology, serology and histopathology examination. Results of the present study revealed safety of stem bark and leaves extract of Ficus gibbosa Linn. in SD rats up to dose of 2000 mg /kg B.W and 1000 mg/kg BW upon single exposure and 28 days consecutive oral administration respectively.

Keywords: Ficus gibbosa, stem bark, leaves, toxicity, rats.