Abstract

DEVELOPMENT AND EVALUATION OF RAPIDLY DISINTEGRATING TABLETS OF CANDESARTAN

Mohammad Pravej Ansari*, Md. Majid Iqbal and Rohit Saraswat

Abstract

In the present work, Rapidly disintegrating tablets of Cadesartan cilexetil were designed with a view to enhance patient compliance by direct compression method. In the direct compression method, crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants were used along with Sweeteners and flavours were used to enhance the organoleptic properties of tablet. Tablets were prepared by direct compression technique. Directly compressible microcrystalline cellulose to enhance mouth feel. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in -vitro disintegration time, drug content and in vitro drug release. Short-term stability (400C/ 75% RH for 3 months) and drug-excipient interaction study (IR spectroscopy) are also were studied. Disintegration time and drug release were taken as the basis to optimize the rapidly disintegrating tablet. All the formulations were evaluated for the influence of disintegrates and their concentrations on the characteristics of rapid disintegrating tablets mainly in terms of disintegration time and dissolution studies. The disintegration time of all formulation showed less than 37 seconds. Among the three superdisintegrants used, Crospovidon showed less disintegrating time followed by crosscarmellose sodium and sodium starch gycolate. The relative efficiency of different superdisintegrants to improve the drug rate of tablets was in order, crospovidon> Crosscarmellose sodium >sodium starch gycolate.

Keywords: Rapid disintegrating tablet, superdisintegratants, Candesartan celixitle. Crospovidone; Croscarmellose sodium; Sodium starch glycolate.