World Journal of Pharmaceutical Research (WJPR) has indexed with various reputed international bodies like :

WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

User Name :

Password :

Forgot Your Password? | Register

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Track Your Article

Abstract

EFFICIENT SCALABLE APPROACH FOR CLOPIDOGREL BISULFATE THROUGH PREFERENTIAL CRYSTALLIZATION OF(±)-2-(2-CHLOROPHENYL)-(6,7-DIHYDRO-4HTHIENO[ 3,2,C]PYRIDINE-5-YL-ACETAMIDE.

M. M. V. Ramana* and Rajesh K. Rao.

Abstract

The present work deals with the efficient synthesis of Clopidogrel Bisulfate (Generic name : Plavix by Sanofi) through resolution of an important precursor (±) -2-(2-chlorophenyl)-(6,7-dihydro-4Hthieno[ 3,2,c]pyridine-5-yl-acetamide by preferential crystallization. This compound was synthesized in its racemic form as per the known process and was resolved by preferential crystallization. These efforts led to a successful isolation of enantiomerically pure isomers of (±)-2- (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2,c]pyridine-5-ylacetamide.

Keywords: Clopidogrel Bisulfate, Preferential Crystallization, Racemic compound, Conglomerate, Racemization.

[Full Text Article]