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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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ICV : 90.8

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Abstract

A MICROWAVE ASSISTED ONE â€“ POT SYNTHESIS OF TICLOPIDINE HYDROCHLORIDE THROUGH 4,5,6,7- TETRAHYDRO (3,2-C) THIENO PYRIDINE HYDROCHLORIDE

M. M. V. Ramana* and Rajesh K. Rao.

Abstract

The microwave assisted Pictet Spengler reaction of thiophene ethyl amine and formaldehyde afforded 4,5,6,7-tetrahydro (3,2-c) thieno pyridine hydrochloride (I), which was then subjected to alkylation with 2-chloro benzyl chloride under microwave conditions to afford Ticlopidine Hydrochloride, thus making it one-pot, efficient and economical approach.

Keywords: Ticlopidine Hydrochloride, Pictet-Spengler, Schiff base, Alkylation, Microwave.

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