Abstract

PHARMACOLOGICAL SCREENING OF PEPGARD SYRUP BY ANTI-OXIDANT AND ANTI-ULCER ACTIVITY

Amit Patel*, Dr. Komal Hirani, Dr. Vishva Bhuva and Payal Panchal

Abstract

Background: Pepgard syrup is a proprietary Ayurvedic poly-herbal formulation widely used in clinical practice as Antacid for treating Heartburn, dyspepsia, Gastroesophageal reflux (GERD) and Druginduced gastritis. There is conflicting reports regarding its anti-ulcer and ulcerogenic potential. Aims and Objectives: The study is with the aim of determining the gastoprotective effect of Pepgard syrup on aspirin-induced gastric ulcer in rats. Materials and Methods: Wistar Albino rats strains were used for the study. Aspirin was purchased from Sigma Labs, Mumbai. Anti-ulcer effect was studied in rats after inducing mucosal damage by aspirin. Results: It was found that extract of Pepgard syrup exhibited significant protection against aspirin-induced ulcer at dose levels of 100 mg/kg body weight. There is a dose-dependent increase in the ulcer protective action of the extract. Conclusion: The present study of Pepgard syrup revealed its anti-ulcer and Anti-oxidant activity.

Keywords: Pepgard syrup, Anti-ulcer; Aspirin Ulcer Index, Anti-oxidant.