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Abstract

FORMULATION AND EVALUATION OF OPHTHALMIC IN-SITU GEL FOR THE TREATMENT OF OCULAR INFLAMMATION AND BACTERIAL INFECTION

Umalkar D. G.*, Dhondkar J. K., Dama G. Y. and Bidkar S. J.

Abstract

In this present work describes the formulation and evaluation of ocular drug delivery system of Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate based on the concept of pH triggered in-situ gelling system. A combination of Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate along with carbomer as pH sensitive polymer was used to formulate pH triggered in-situ gel. The developed formulation was alternative to conventional ophthalmic dosage form to improve the contact time of the drug in eyes. Moxifloxacin as an antibacterial agent and Dexamethasone as corticosteroids, this two drugs combination in-situ gel dosage form is used to treat bacterial infection and ocular inflammation. The developed formulation was effective in the treatments of bacterial infection and ocular inflammation. The formulation which follows sol gel transition system i.e. eye drops instilled into eye which undergo gel form therefore increase the residence time of the drug into the eye. In these formulations carbomer is used as gelling agent which exhibit sol gel phase transitions due to change in physicochemical parameter (pH) & HPMC used as viscosity enhancer. The formulations were evaluated for the clarity, pH, gelling capacity, drug content, rheological study, in vitro drug release study, stability study.

Keywords: Moxifloxacin Hydrochloride, Dexamethasone Sodium Phosphate, Cabomer In situ gelling system, pH triggered method.


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