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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

A NOVEL AND FACILE ONE STEP PROCEDURE FOR THE SYNTHESIS OF 2-SUBSTITUTED BENZIMIDAZOLES FROM ONITRO ANILIDES IN AQUEOUS MEDIA

Dasari Raju , Gaddam Prabhakar, Dr.B.Madhavarao, Dr. B.M.Choudary *

Abstract

A new method for the synthesis of 2-substituted N-H benzimidazoles was achieved in one step by reaction with Na2S2O4 via a reductive cyclo dehydration of o-nitro anilides in water. It was observed that Methanol or Ethanol could also be used as co-solvent. This method provides facile access to a series of 2-substituted N-H benzimidazoles (la-ln) containing various functional groups in good to excellent yields.

Keywords: Benzimidazoles, water, cyclodehydration, sodium dithionite.

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