Abstract

OMEGA-3 POLYUNSATURATED FATTY ACIDS, LIPID PROFILE, INSULIN RESISTANCE AND DIABETIC CARDIAC AUTONOMIC NEUROPATHY

Samir Ajmi, Victoria A. Serhiyenko*, Ludmila M. Serhiyenko, Alexander A.
Serhiyenko

Abstract

Background: The significance of cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM) has been not fully appreciated and there is no unified treatment algorithm. Aim: The aim of study was to investigate the effects of -3 polyunsaturated fatty acids (-3 PUFAs) on blood lipid profile and insulin resistance (IR) parameters in patients with T2DM and definite CAN. Patients and Methods: The study involved 33 patients with T2DM and definite CAN. Patients were allocated into two treatment groups: 1st group - 15 patients received standard hypoglycaemic therapy - control (n = 15); 2nd group (n = 18) - standard hypoglycaemic therapy and 1 capsule/day of the ω-3 PUFAs (1 g, including 90 % ω-3 PUFAs) for three months. The concentrations of glucose, glycated haemoglobin A1c, immunoreactive insulin in the blood were determined. Lipid metabolism was assessed by the concentration of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) measurements. The insulin resistance Homeostasis model assessment, atherogenic coefficient (AC), TG/LDL-C, TG/TC, TG/LDL-C and TG glucose (TyG) index were calculated. Results: Obtained results of our study could witness that the prescription of -3 PUFAs was accompanied by a statistically significant decrease in TG concentration; AC, TG/LDL-C, TG/TC, TG/LDL-C, TyG index parameters and increase in HDL-C levels (compared to control). Conclusions: Obtained results justify the appropriateness of -3 PUFAs prescriptions to patients with T2DM and definite CAN.

Keywords: Type 2 diabetes mellitus, Cardiac autonomic neuropathy, Lipids, Insulin resistance, ?-3 polyunsaturated fatty acids.