Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION CHARACTERISTICS OF FUROSEMIDE BY SOLID DISPERSION TECHNIQUE

D. Christopher Vimalson*, S. Anbazhagan, L. Gokul, S. Idhayadharani, S. Ranjith, J. Sabarinathan and R. Surya

Abstract

Furosemide is practically insoluble in gastric fluid and having high permeability through stomach was selected. The present study was to improve the solubility and dissolution of Furosemide by increasing the solubility in water by solid dispersion methods like fusion and solvent evaporation method using hydrophilic polymers poly ethylene glycol 4000 and Povidone K 32. Solid dispersion techniques are predominantly promising for enhancing the oral absorption and bioavailability of the BCS Class II drugs. Compatibility studies for drug and excipients was done by FTIR. Solid dispersions of Furosemide was formulated using polar ploymers like PEG 4000 and PVP K32 either by fusion method or solvent evaporation method in four ratios like 1:1, 1:2, 1:3, 1:4. The prepared solid dispersions were characterized for Solubility, Drug Content, Flow Properties: Angle of Repose, Carr’s Index and Average Particle Size, Physical Properties: Bulk density, tapped density and Hausner’s ratio. Particle Morphology by using scanning electron microscopy and In Vitro drug release studies. Solid dispersions of FE prepared by fusion and solvent evaporation methods employing PEG 4000 and PVP K32 i.e. SDFE3 and SDFE7 were exhibited greater solubility and dissolution rate when compared to pure drugs. The micrometrics parameters and flowability observed to be excellent flow characteristics and fair Hasuner’s index. Based on the in vitro drug release profiles of respective solid dispersions and their capsules it is concluded that solubility and dissolution rate of FE is increased by using the PEG 4000 and PVP K32 polymers. On comparing with the PEG 4000 and PVP K32 prepared by fusion and solvent evaporation for Furosemide, SDFE3 is having high solubility and dissolution rate when compared with SDFE7.

Keywords: Furosemide, PEG 4000, Povidone K32, Solid Dispersion.