Abstract

CHARACTERIZATION OF GREVILLEA ROBUSTA GUM TO ESTABLISH IT AS A PHARMACEUTICAL EXCIPIENT

Darekar A.B., Kahane J.U., Saudagar R. B., Gondkar S.B., Chavan M.J.,
Ashawat M

Abstract

The gums are common constituents of plants, and being used in pharmaceutical and in other various industries due to their abundance in nature, safety and low cost. The present study was undertaken to isolate gum from the plant of Grevillea robusta, to explore its use as a pharmaceutical excipient. The isolated gum was evaluated for various physico-chemical characterizations.The parameters applied from the present study include solubility, hygroscopicity study, moisture content, ash values, swelling index hydration capacity, angle of repose, bulk and tap densities, hausner’s ratio, compressibility index, pH value, rheological study, microbial count, acute toxicity study. The results obtained in the acute toxicity study indicates that Grevillea robusta gum did not produce any visible toxicities or mortality with oral doses up to 2000 mg/kg within 24 hrs of single treatment. Scanning electron microscopy (SEM), X-ray powder diffraction (XPRD), Differential scanning colorimetry (DSC), and Fourier transmittance infra red (FTIR), were used to characterize the gum sample which can be used further for the formulation development.

Keywords: Grevillea robusta, hygroscopicity, Differential scanning colorimetry