Abstract

NASAL DRUG DELIVERY SYSTEM: A REVIEW

Sunitha Reddy M.* and Manasa Tadi

Abstract

Since many years drugs have been administered by the nasal route for treating local infections such as congestion, rhinitis, sinusitis etc. several drugs such as corticosteroids, antihistamines, vasoconstrictors and anticholinergic drugs have been used for local delivery of drugs through the nasal route. The nasal drug delivery system is a promising route when compared with the other drug delivery routes thus it will provides a patient compliance, self-administration, good penetrating capability, rapid absorption and bypasses first pass metabolism it requires low dose and gives desirable effects. The nasal route is most preferred route for the drugs restricted to IV administration because of large surface area porous endothelial membrane, high blood flow and ready accessibility from nasal cavity. Recently peptide and protein drugs are investigated for systemic medication. It is favorable route because the drugs are rapidly cleared from nasal cavity. It is also well suitable for delivery of biotechnological products like proteins, peptides, hormones, DNA plasmids for DNA vaccine delivery.

Keywords: Nose, bioavailability, anatomy, barriers, enhancers, potential pathways, factors, drug delivery systems and devices.