Abstract

SYNTHESIS OF 2-(3,4-DICHLORO-BENZOYL)-BENZOIC ACID HYDRAZIDE DERIVATIVES AND ASSESSMENT OF ANTIMICROBIAL EFFICACY AGAINST E. COLI AND B. SUBTILIS

Pallavi Singh*, Anil Kumar Meena, R. K. Singh and Jyoti Singh

Abstract

Emergence of multiple drug resistant microbial species is an arena of serious concern all over the globe. Hydrazone derivatives have been assessed to possess significant antimicrobial, antimycotic, antiinflammatory and anticancerous properties and they have been demonstrated to be a key solution to treat these microbial species which display multiple drug resistance. In current work, a series of hydrazone derivatives were synthesized and evaluated for antibacterial activity against Escherichia coli and Bacillus subtilis using Disc diffusion assay. 2-(3,4-dichloro-bezoyl)-benzoic acid (2-oxo-1,2- diphynyl-ethylidene)-hydrazide (HDZ-1), 2- (3,4-dichloro-bezoyl)-benzoic acid (2-hydoxy- 1,2-diphynyl-ethylidene)-hydrazide(HDZ-2), 2- (3,4-dichloro-bezoyl)-benzoic acid [1-(4- methoxy-phenyle)-ethyledene]-hydrazide (HDZ-3), 2-(3,4-dichloro-bezoyl)-benzoic acid [1- (4-bromo-phenyle)-ethyledene]-hydrazide(HDZ-4) 2- (3,4-dichloro-bezoyl)-benzoic acid [1- (4-chloro-phenyle)-ethyledene]-hydrazide (HDZ-5) were the five key derivatives of hydrazone which were fabricated and tested for antibacterial activity against E.coli and B.subtilis.

Keywords: Hydrazone, E.coli, B.subtilis, Disc diffusion, NMR Spectra.