Abstract

EFFECT OF KALYANA KSHARAM ON ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN RATS

Padmapriya G., Vimalavathini R.* and Kavimani S.

Abstract

Aim And Objective: To appraise the antiurolithiatic activity of Kalyana Ksharam (KK)- an herbo mineral formulation against ethylene glycol and ammonium chloride induced urolithiasis in rat. Materials And Methods: Effect of KK were investigated on calcium oxalate urolithiasis. Five groups of male albino rats (n=6) were used to study the antiurolithiatic activity of KK. Expect Group I which served as normal control, group II-V received 1% ammonium chloride and 1% ethylene glycol, group III with cystone (500 mg/kg, p.o) and group IV and V with low (200 mg/kg, p.o) and high (400 mg/kg, p.o) dose of KK for 7 days. On 8th day 24 h urine and blood sample was collected for biochemical analysis and histopathological examination of kidney were done. Results: Urolithiatic rats showed increased serum calcium, uric acid and BUN level but the KK treated group significantly reduced the level of this above parameter. The urinary oxalate level decreased and urinary magnesium and uric acid level increased in treatment group when compared to urolithiatic group. Histopathological examination depicted absence of calcium oxalate (CaOx) in KK treated group. Conclusion: It is concluded that KK had protective effect against ethylene glycol and ammonium chloride induced urolithiasis in male albino rat.

Keywords: Ethylene glycol, Ammonium chloride, Urolithiasis.