Abstract

IN-SILICO STUDY OF GERANIOL ANALOGS AGAINST EGFR FOR VALIDATING ITS POTENCY TO BE CANDIDATE CANCER DRUG

Swechha Mishra*

Abstract

Receptor tyrosine kinase is a key regulator of various physiological pathways. Anomaly in this protein might lead to cancer, and therefore it holds great potential to be potent target for combating cancer .With the aim of validating effect of geraniol analogs on tyrosine kinase, insilico screening was carried out. In this study we have taken different geraniol derivatives and performed molecular docking against receptor tyrosine kinase in order to check the efficiency of docking. Further toxicity test was performed to detect the compatibility of selected compound to that with the human system.

Keywords: Geraniol, EGFR, Auto dock, Docking.