Abstract

ALTERATIONS OF VITAMIN D RECEPTOR GENE POLYMORPHISM AND HYPERPARATHYROIDISM IN END STAGE RENAL DISEASE

Nashwa Abdelelah Mohamed*, Mohamed Abd-El Moniem Mahmoud, Ayman El-Baz El-Agroudy and Abdel-Aziz Fotouh Abdel-Aziz

Abstract

This study included 65 chronic renal failure patients and 25 healthy volunteers as normal control group. Deficiency of vitamin D is associated with high level of iPTH leads to development of secondary hyperparathyroidism (sHPT).This study estimated that the levels of 25(OH) D and calcium were significantly lower; on the other hand, the levels of serum phosphorus and iPTH were significantly higher in comparison with those in the control group. It was observed that there were significant negative correlations between serum iPTH and 25(OH) D levels, Phosphorus and 25(OH) D levels and serum calcium and phosphorus levels in chronic renal failure patients. On the other hand, there were significant positive correlations between serum calcium and 25(OH) D levels also, between serum iPTH and phosphorus levels. Vitamin D receptor (VDR) gene FOKI polymorphism plays an effect role on iPTH level in chronic renal failure patients. In this study there were significant differences of iPTH levels in genotype groups of FOKI gene polymorphism in CRF patients as FF genotype patients had a higher level of iPTH than Ff and ff genotype patients.

Keywords: Chronic renal failure, intact parathyroid hormone, Secondary hyperparathyroidism, Vitamin D.