Abstract

A REVIEW ON FORMULATION OF GLICLAZIDE NANOSUSPENSION BY PRECIPITATION METHOD

Paladugu Raja Saran*, R. B. Desireddy, G. Sivareddy, G. Suresh, G. Avulaiah, G. Naga Durga Prasad and K. Raghavendra Rao

Abstract

In the present study, an attempt was made to prepare Nanosuspension of Gliclazide which is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Nanosuspension containing the drug was prepared by precipitation method using combination of polymers such as PVP K-30, poloxamer (407), Sodium lauryl sulphate (SLS), and acetone. Estimation of Gliclazide was carried out spectrophotometrically at 232nm. The Oral Nanosuspension were evaluated for various physical and biological parameters, drug content uniformity, particle size analysis, zeta potential, in-vitro drug release, short-term stability, drug-excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulations F1 to F9 (containing PVP K-30, Eudragit S 100, SLS, Poloxamer (407), and Acetone) used different ratio were found to be promising, of that formulation F9 containing Eudragit S 100 and PVP K-30 releases 99.43% at the end of 20min & it follows first order drug release kinetics. These formulations have displayed good Nanosuspension strength.

Keywords: Gliclazide, Nanosuspension, PVP K-30, SLS, poloxamer (407), and Methanol.