Abstract

ASSESSMENT OF ANTI-DEPRESSANT ACTIVITY OF A POLYHERBAL FORMULATION BC019

Chinna Rao V. and Brahma Srinivasa Rao Desu*

Abstract

In our present study, the anti-depressant effect of polyherbal formulation BC019 was assessed using two behavioral models, the forced swim test (FST) and tail suspension test (TST) in rats in in-vivo. In FST & TST, BC019 showed a dose dependant, statistically significant reduction in duration of immobility that was similar to imipramine (20mg/kg).The effect of 400mg/kg of BC019 was better than standard drug imipramine. The effect of 200mg/kg of BC019 was significant when compared to vehicle treated group. These results proved that the polyherbal formulation BC019 possessed antidepressant activity in in-vivo.

Keywords: Anti-depressant, Forced swim test, Tail suspension test, imipramine, rats, immobility.