Abstract

CASE REPORT ON LOSARTAN INDUCED STEVENS JOHNSON SYNDROME

Gikku Mariyam Varghese*, Deepa Koshy and Dr. Abel Abraham Thomas

Abstract

Steven-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is one of the dermatologic conditions that can be potentially fatal. Steven-Johnson syndrome is an infrequent and a severe form of erythema multiform (EM). It is considered to be a less severe form of toxic epidermal necrolysis (TEN). SJS is most commonly triggered by medications, characterized by extensive necrosis and detachment of the epidermis. SJS can be differentiated from other skin conditions on three clinical criteria, (i) the pattern of individual skin lesions, (ii) distribution of lesions, and (iii) extent of epidermal detachment. Losartan belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease. SJS by use of Antihypertensive Drug (Losartan) is rare.

Keywords: Stevens-Johnson Syndrome, Losartan, Cutaneous Reaction.