Abstract

EFFECT OF ETHANOLIC FRUIT EXTRACT OF Prunus persica LINN. ON MARKERS ENZYMES IN ETHYLENE GLYCOL INDUCED RATS

*Shamina S.

Abstract

The ethanolic extract of Prunus persica was studied for antiurolithiatic property in ethylene glycol induced wistar rats by oral administration of extract in 150 mg/kg body weight for 28 days. The effect was measured with standard drug with the oral dose of 1mg/kg thiazide for a period of 28 days. The study estimated the effect of ethanolic fruit extract on marker enzymes in urine, liver and kidney. Prunus persica fruit extract showed a significant increase in AST, ALT, ACP and ALP activities in the liver and kidney when compared to ethylene glycol treated rats shows the indication of recovery proving the membrane stabilizing property and it also proves that the ethanolic fruit extract of Prunus persica normalized the levels of marker enzymes in tissues showing the anti-urolithiatic potential. Thus, it is concluded that Prunus persica has significant anti-urolithiatic activity in ethylene glycol induced wistar rats.

Keywords: Urolithiasis, AST, ALT, Calcium oxalate, Prunus persica.