Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER (II), COBALT (II),NICKEL (II) AND MERCURY (II) COMPLEXES OF SCHIFF BASE DERIVED FROM 2-ACETYL-5- CHLORO THIOPHENE 5-AMINO-1,3,4-THIADIAZOLE-2-THIOL

Dr. Mohammed. Fakruddin Ali Ahamed*

Abstract

The biologically active Schiff base (imines) was synthesized by the reaction of 2-acetyl-5-chloro thiophene and 5-amino-1, 3, 4- thiadiazole-2-thiol in the presence of conc. Acid. The characterization of Schiff bases were carried out by using elemental analysis and VSM including IR, 1H -NMR, EI-MS analyses. The Schiff bases were checked for biological screening and found that the compound with - SH group to be more biologically active than the compound with halo (-X) group. Job’s continuous variation method and Mole ratio method revealed 1:2 metal to ligand ratio, by chelation of metals Cu (II) Co (II),Ni (II), and Hg (II) with octa-dentate complexes were synthesized.

Keywords: octa-dentate Schiff base, 2-acetyl-5-chloro thiophene-5-amino-1, 3, 4- thiadiazole-2-thiol, VSM, Biological activity.