Abstract

FORMULATION CHARECTERISATION AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF KETOPROFEN WITH DIFFERENT POLYMER CONCENTRATION

Dr. S. Chandra*, A. Sheikalisha*, Aswathy Raj S., R. Suresh, B. Nandhini and S. S. Angeetha

Abstract

Transdermal drug delivery system is a new era of pharmaceutical dosage forms along with various features to provide successful drug delivery. Transdermal drug delivery system establishes itself as an integral part of novel drug delivery system. In the present study, an attempt was made to design and evaluate transdermal patches of Ketoprofen, in order to overcome first pass metabolism in GIT, drug deactivation by lever and better patient complaints and to reduce adverse effect and frequency of administration. Each of the proposed transdermal patches is composed of using different polymers, anticipating rapping drug permeation and drug release. Controlled released transdermal preparation of Ketoprofen prepared to give sustained effect as compared to conventional multiple oral dose. The patches were prepared by solvent evaporation method using polymers such as ethyl cellulose and polyvinyl pyrrolydine. The prepared patches were evaluated for thickness, weight variation, folding indurance, surface PH, tensile strength, percentage flatness, swellability, percentage moisture update, drug content uniformity, invitro permeation, in vitro drug release. In vitro drug release studies were perfomed by using USP type second apparatus (paddle method) at 50 rpm in 900 ml of 7.4 phosphate refer for 8 hour at 37+_ 0.5oC. In vitro permeation studies were franz diffusion cell apparatus with 7.4 phosphate buffer for 10 hours. Transdermal drug delivery had become an appealing and patience acceptance technology as it is minimize and avoids the limitations while comparing with conventional as well as parenteral route of drug administration such as peak and valley phenomenon i.e. exhibit fluctuation in plasma drug concentration level, pain and inconvenience of injections and the limited controlled release options of both. A transdermal patch is defined as medicated adhesive patch which is placed above the skin to deliver a specific dose of medication through the skin with a predetermined rate of release to reach into the blood stream.

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