Abstract

FORMULATION & EVALUATION OF IMIPENEM LOADED CALCIUM CARBONATE NANOCRYSTAL HYDROGEL

Vipresh Bhardwaj and Balwan Singh*

Abstract

The objective of this study was basically to increase the solubility as well as the permeability of the low water soluble & low permeable drug Imipenem. This is done by converting the drug into nanocrystal formulation. This type of formulation comes under the category of having many dimensions of size 100 nm or less than it because nanocrystals have the ability to alter the physical & chemical properties of the drug. The method of preparation of calcium carbonate nanocrystals used was precipitation method and they synthesized by scanning electron microscopy. Drug release study of final product done by using HPLC method and imipenem calcium carbonate nanocrystals finally loaded in Acrylamide hydrogel to make it unique formulation respectively.

Keywords: Imipenem, Calcium Carbonate, Nanocrystals, Hydrogel.