Abstract

BIOASSAY-GUIDED ANTIDIABETIC MECHANISMS OF CINNAMOMUM INERS LEAVES EXTRACT

Fazlina Mustaffa*, Zurina Hassan, Nur Adlin Yusof, Khairul Niza Abdul Razak Mohd Zaini Asmawi 

Abstract

Background:Cinnamomum iners has been traditionally claimed to be consumed by diabetic patients as natural supplements. However, no scientific data is available to validate the folklore claim.. Hence, this study evaluated the antidiabetic mechanisms of active methanol extract, active chloroform fraction and active subfraction 1 of C. iners leaves which is the extension from our previous study. Methodology: The possible antidiabetic mechanism was validated using ex vivo model and immunochemistry procedure. In addition, the insulin stimulatory effect of active extract, active fraction and active subfraction of C.iners was determined using rat insulin ELISA kit. Results: Our study demonstrated that the antihyperglycaemic effect of C. iners leaves is mediated both, at pancreatic level by direct stimulation of insulin and at peripheral level by increasing glucose uptake by muscle. Conclusion: Our study clearly justified the use of this plant in the indigenous system of medicine

Keywords: Cinnamomum iners, antidiabetic mechanism, antihyperglycaemic.