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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

P-GLYCOPROTEIN â€“ A REVIEW

Stephen I., Vimalavathini R.*, Kavimani S. and Subhashri SHR

Abstract

P-glycoprotein (P-gp), an efflux transporter aimed to pump hydrophobic toxins and xenobiotics thus preventing their toxicity. It is widely distributed in most body tissues and belongs to the ATPbinding cassette family of transporter molecules. It has major implications in pharmacokinetics, pharmacodynamic, chemotherapeutic drug resistance, drug interactions genetic polymorphism and diseases. This review summaries the various aspects of this P-gp implication.

Keywords: P-glycoprotein, induction, inhibition.

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