Abstract

INSITU GEL: AN OVERVIEW ON FLOATING INSITU GEL FOR ORAL DELIVERY

Vasu L.*, Ganesh N. S. and Vineeth Chandy

Abstract

Oral route technique is used over a decades. It is most common technique for oral administration of drug in the body, due to certain limitations drug targeting to particular organ can cause problem for administration through oral route. In order to overcome this problem a novel approach is developed i.e. Insitu Drug Delivery System. In-situ gel is a process in which solution form before administration in the body, but once administrated, it undergoes gelation in-situ, to form gel. The floating in situ gel forming systems are one of the most interesting systems in oral drug delivery. To prolong the gastric residence time and control the rate of drug release which can improve oral bioavailability and reduce frequency of dosing. The main aim of this review is to focus on insitu gel principle, mechanism, properties, advantages, and its formulation, evaluation, and applications as floating insitu gel system.

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