Abstract

ENHANCEMENT OF SOLUBILITY OF POORLY SOLUBLE DRUGS BY LIQUISOLID COMPACT TECHNIQUE

G. Y. Srawan Kumar* R. B. Desireddy, P. Kasi Reddy, S. Saikrishna Reddy, S. Durga Prasad and U. Naga Ravi

Abstract

Most of newly developed drugs of about 40-50% are lipophilic and poorly water soluble. Enhancement of dissolution and bioavailability of the drugs is a major challenge for the pharmaceutical industry. Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert to acceptable flowing compressible powders by blending with selected powder excipients. By using this method dissolution rate and bioavailability of Biopharmaceutics Classification System (BCS) class-2 drugs can be increased. It is a novel and advanced approach to tackle the issue. The objective of this article is to present over view of liquisolid technique and its applications in pharmaceutical industry and also study the methods of pre compression parameters like Angle of repose, Bulk density, Tapped density, Carr’s index and Hausner’s ratio and post compression parameters such as Weight variation, Thickness, Hardness, Friability, Disintegration tests, In vitro drug release test, Differential Scanning Calorimetry (DSC), X-Ray diffraction, Scanning Electron Microscopy (SEM). Overall, liquisolid technique is newly developed and promising tool for enhancing drug dissolution and sustaining drug release.

Keywords: Liquid medication, Liquisolid compacts, Liquid Load Factor (Lf), Coating material ratio (R), Carrier material, Coating material.