Abstract

CO-SOLVENCY AND ANTI-SOLVENT METHOD FOR THE SOLUBILITY ENHANCEMENT: AN OVERVIEW

Vishakha Vishwanath Doke*, Abhijeet Sunder Kunwarpuriya, Dr. Khemchand Gupta and Dr. Nilesh M. Khutle

Abstract

Solubility is one of the important parameters to achieve desired concentration of drug in systemic circulation for pharmacological response to be the show. There is the various factor are responsible for poor solubility of a drug in systemic circulation. Hence various techniques are used for the improvement of the solubility of poorly water-soluble drug includes varies techniques in which antisolvent and cosolvency method are described below. Cosolvency and antisolvent crystallization technique are being used to prepare nanoparticles or micro particles for poorly water soluble drugs at research scale. This method has an ability to change the solid-state properties of pharmaceutical substances including the modification of crystal formation and particle size distributions. Due to this technique to achieve desirable systemic circulation.

Keywords: Solubility, Co-solvency, Anti-solvent.