Abstract

AN UPDATE AND LITERATURE REVIEW: BENZIMIDAZOLES AS ANTI CANCER AGENTS

Thatikayala Mahender*

Abstract

Cancer is the most important dreadful diseases in the world. It is characterized by uncontrolled proliferation of cells. The women are more prone to cause the cancer compare to men. World wise the most of the peoples are suffering by breast, lung, and colorectal cancer. There are some factors responsible to cause the cancer they are genetical factors, behavioral risk factors, physicalrisk factors. Global data announced that there may be a chance to a rise 21.4 million cases per year with 13.2 million deaths by 2030. Benzimidazole and its are important heterocyclic compounds having wide variety of pharmacological actions like anticancer, acetylchlinesterase, antimicrobial, anti inflammatory, analgesic, antileishmanial activities hence its attracts the researcher to develop many active compounds in medicinal chemistry. The present review reveals that many substituted benzimidazoles as anti cancer agents against many type of cancer celllines.

Keywords: Antiancer, Benzimidazoles, Acetylchlinesterase, Pharmacological, Antileishmanial.