Abstract

DESIGN AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLET OF ZIDOVUDINE BY USING COMBINATIONS OF DIFFERENT POLYMER

Anurag Singh*, Dr. Surendra Kumar Jain, Nitin suryawanshi and Priyanka Chaturvedi

Abstract

The matrix system is one of the intricate approaches for the preparation of the sustained release dosage forms. formulation of matrix tablet has gained immense popularity now a day because it has the advantage of simple processing and low cost of fabrication. formulated oral sustained release matrix tablets of zidovudine in order to improve efficacy, reduce the frequency of administration, and better patient compliance. Matrix tablet of zidovudine were formulated by wet granulation method using 5% PVP K-90 paste as the binder talc and magnesium stearates as lubricants. The present study was carried out to develop and evaluate the matrix tablets of zidovudine containing HPMC, XG, GG as release modifying polymer. The physicochemical compatibility of the drug with polymers was established through FTIR spectroscopy. Zidovudine sustained release matrix tablets were prepared successfully by wet granulation using HPMC K100M, GG and XG as polymers in different proportion, to retard the release and achieve required dissolution profile. Therefore it was concluded that HPMCK100M and EC in the ratio of 1:1 (F-5) is suitable for the formulating matrix system of zidovudine. Drug release kinetics of F-5 formulation correspond best to Higuchi model and drug release mechanism as per n-value of Korsmeyer & Peppas (Power law) followed non-Fickian diffusion, that means water diffusion and polymer rearrangement had an essential role in the drug release. results of the current study were indicated, a promising potential of the zidovudine matrix system as an alternative to the conventional dosage form. Since the polymer and the drugs were found to be compatible and the release mechanism is characterized, there is a great scope for the formulation of this anti-HIV drug as a matrix system.

Keywords: Zero order kinetics, Higuchi model, zidovudine, non- Fickian, PVP K-90.