Abstract

SYNTHESIS, CHARACTERIZATION AND MOLECULAR DOCKING STUDIES OF ARYLOXYPROPANOLAMINES

Raviteja Bandla*, M. Prasada Rao, B. Prabhudeva, B. Sravanthi, Ch. Nageswara Rao, G. Rajeswari and T. Neelima

Abstract

Molecular docking was done on protein which is Turkey Beta-1 Adrenergic receptor with Stabilising mutations and bound against Isoprenaline (2Y03) is selected for docking with a ligand,1-(4-(3-(4- amino-5-(4-chlorophenyl) pyrimidin-2-ylamino)-2- hydroxypropoxy)phenyl)ethanone (AOP 1) as ligand which forms protein-ligand complex having high binding affinity & is selected for synthesis by taking p-hydroxy acetophenone & epichlorhydrin as substrates & reactants respectively. Methanol and amines are also used as reactants.

Keywords: 1-(4-(3-(4-amino-5-(4-chlorophenyl)pyrimidin-2 -ylamino)-2-hydroxypropoxy)phenyl)ethenone (AOP 1), Turkey Beta-1 Adrenergic receptor with Stabilising mutations and bound against Isoprenaline (2Y03).