Abstract

NIMESULIDE INDUCED STEVENS-JOHNSON SYNDROME – AN ADVERSE DRUG REACTION

Salwa Mehrin*, Uzma Parveen, Safura Sultana and Rehab Rafi

Abstract

Adverse drug reaction is one of the serious clinical issues of concern in the modern-day pharmacotherapy, there forth imposing a threat to patient wellbeing. Stevens-Johnson Syndrome is a rare, serious and potentially life-threatening cutaneous reaction, primarily involving skin and muco cutaneous ulcerations, notably caused by drug intake and other intermittent infections. This case substantially highlights the importance of Nimeusulide as the primary agent causing Stevens- Johnson Syndrome hence, its use should be judiciously monitored in order to prevent such fatal reactions. We report a case of 27-year-old female presented with vesicular rupture in eye, oral cavity, throat, and genital area associated with burning micturition, odynophagia and pus discharge. On the whole, comprehensive clinical and laboratory findings confirmed the diagnosis as Nimesulide induced Stevens-Johnson Syndrome.

Keywords: Stevens-Johnson Syndrome (SJS), Nimesulide, Naranjo?s ADR probability Scale.