Abstract

HYDROTROPIC SOLUBILIZATION TECHNOLOGY AN ECOFRIENDLY ANALYSIS TO IMPROVE SOLUBILITY, DISSOLUTION AND BIOAVAILABILITY OF VARIOUS POORLY WATER SOLUBLE ANTIVIRAL DRUGS

Hajera N. Khan*, Bansode Rani and Supriya Harale

Abstract

Solubility is one of the most essential parameter to achieve desired concentration of drug in the systemic circulation for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility of various drugs. Several drugs also show side effects due to their poor aqueous solubility. There are various techniques are used to enhance the aqueous solubility of poorly watersoluble drugs and hydrotropic solubilisation technique is one of them. A hydrotrope is one of the compound that solubilizes hydrophobic compounds in aqueous solution. Various antiviral drugs belongs to class iv in biopharmaceutics classification system (BCS). The major problem of this drug having poor solubility in biological fluid which result in poor bioavailability after oral administration. Hydrotropic solubilization technique is the best approach to increase the water solubility of poorly water-soluble drugs and overcome problem-related with organic solvents. This review investigates the characterstic of hydrotropy and hydrotropic agents and their different advance toward the pharmaceutical analysis. This review also provides the future prospective concerned with the green pharmaceutical analysis.

Keywords: hydrotropy, Ecofriendly analysis, solubility, antiviral drugs.