Abstract

INVESTIGATION OF THE EFFECTS OF THE ETHYL ACETATE ROOT EXTRACT OF SPHENOCENTRUM JOLLYANUM ON SOME BIOCHEMICAL PARAMETERS OF ALLOXAN-INDUCED DIABETES IN RATS

Arinzechukwu N. Nwokoma, Christian E. Odo, Simeon I. Egbachukwu and Humphery Omeoga

Abstract

This study was aimed at evaluating the effects of the ethyl acetate root extract of S. jollyanum on the concentrations of sera total proteins, albumin, total bilirubin and glucose in rats. Twenty albino male rats were used for the study and divided into five groups (groups A - E) of four rats each. Group A served as the normal control while Groups B-E were made diabetic and group B treated with the standard anti-diabetic drug (glibenclamide at the dose of 5 mg/kg body weight). Group C represented the untreated diabetic rats. Groups D and E were treated with the 200 and 400 mg/kg body weight of the extract respectively. The study lasted for 14 days. After the 14th day, the rats were sacrificed and the blood samples collected via ocular puncture for the determination of the concentrations of the afore-listed parameters. The results showed that there were significant (p

Keywords: Sphenocentrum jollyanum, Total proteins, Albumin, Total bilirubin, Glucose and Diabetes mellitus.