Abstract

A COMPARATIVE STUDY OF DIFFERENT MARKETED FORMULATIONS OF ALBENDAZOLE

N. G. Raghavendra Rao, Yogita Tyagi and Shubhanshu Sidola*

Abstract

The objective of present study is to have comparative study of different marketed formulations of Albendazole. Albendazole is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in the body. There are different types of formulations. Albendazole chewable tablets were prepared by wet granulation method using two superdisintegrants such as croscarmellose sodium and sodium starch granules were evaluated for precompression parameters such as angle of repose, bulk density, tapped density, compressibility index and Hausner's ratio. The formulated tablets were evaluated for diameter, thickness, hardness weight variation, friability, disintegration and drug content. Fast dissolving tablet of Albendazole was design with a view to and provide a quick onset of action. The main objective of the study fast dissolving tablets of Albendazole to achieve a better dissolution rate and further improving the bioavailability of the drug. It precompression parameters. The formulation of Albendazole Suspension is developed on the basis of three trials in which Xanthan gum, Sodium CMC, Sorbitol, Sugar are used in different concentration and also in combination. Evaluation done on the basis el Albendazole Nanosuspension was prepared by solvent diffusion technique followed by sonification. glycolate. A total of eight formulations were prepared and the 1 direct compression and using super disintegrants in different concentration and evaluated for the of the parameters ike Redispersability, Sedimentation, Odor Taste Surfactants plays an important role in the preparation of nanosuspensions. Tween 60 and Sodium Lauryl Sulphate are selected as surfactant which plays a vital role in the preparation of nanosuspensions. Different concations are taken as a formulation variable in the preparation. The prepared nanosuspensions are evaluated for particle size, charge, morphology and solubility.

Keywords: Albendazole, Chewable Tablets, Fast Dissolving Tablets, Suspensions and Nano-Suspensions.