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Abstract

A REVIEW: HYDROXYCHLOROQUINE AND ITS COMBINATION THERAPY WITH ANTIVIRAL DRUG USED NOVEL COVID-19 VIRUS

Anurag Singh*, Priyanka Chturvedi, Dr. Surendra Ku. Jain, Vivek Singh Rajpoot, Manish Sharma

Abstract

A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.[1-3] Chloroquine will act as a prophylactic drug and is acting as a therapeutic agent against COVID- 19 infection chloroquine is a game changer in fight against the COVID-19. Chloroquine acts on host target respiratory cells by Chloroquine increases the endosomal pH required for the virus- host target cell fusion. Increase in the pH disrupts the normal viral function. In SARS-coronavirus, which is a sister to COVID-19, chloroquine was found to interfere with the glycosylation of cellular receptors of the virus. This interference eventually resulted in no association between the host target cell and the virus.[3] Chloroquine had been also proposed as a treatment for SARS, with in vitro tests inhibiting the SARS-CoV virus. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is used to prevent or treat malaria caused by mosquito bites. This medication is also used to treat certain auto-immune diseases (lupus, rheumatoid arthritis). It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis. Hydroxychloroquine is used to tporphyriacutaneatarda, and Q fever, and certain types of malaria. It is widely used to treat primary Jorgen syndrome, but has not been shown to be effective.[9] Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis.Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of quinacrine with less severe side effects. Hydroxychloroquine is a 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities chloroquine will act as a prophylactic drug and is acting as a therapeutic agent against COVID-19 infection chloroquine is a game changer in fight against the COVID-19.[16]

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