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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHETIC APPROACHES FOR THE SYNTHESIS OF DIHYDROPYRIMIDINONES/ THIONES (BIGINELLI ADDUCTS): A CONCISE REVIEW

Vishnu Ashok Adole*

Abstract

Dihydropyrimidinones are considered as vital biological scaffolds due to their involvement in various medicinal activities. As a result of the wide utilization of different Biginelli adducts in various fields the chemistry of the Biginelli motifs has been explored in drug discovery. The present review deals with the investigation of various synthetic methods used for the synthesis of dihydropyrimidinones (DHPMs). Various synthetic methods are discussed in this review to give clear understanding of pathways leading to the formation of Biginelli adducts.

Keywords: Dihydropyrimidinones/thiones, Green chemistry, Biginelli reaction.

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