Abstract

DEVELOPMENT OF SALICYLIC ACID LOADED CLOVE OIL BASED MICROEMULSION FOR TOPICAL DELIVERY

Parthiban S., Sadan P. Gowda* and Senthilkumar G. P.

Abstract

The objective of the present study is to develop Salicylic acid microemulsion system formulated with clove oil for topical drug carrier system for better therapeutic effect. Pseudoternary phase diagrams were used to obtain the concentration ranges of the oil (clove oil), surfactant (Tween 20 and Tween 80) and co-surfactant (Propylene glycol) for microemulsion formation. Four different formulations were formulated with various amount of oil (30 -38%), water (4 -10%) and mixture of surfactant and co-surfactant (58 - 60%). The microemulsion formulation characterized for its % transmittance, viscosity, pH, drug content, surface morphology, zeta potential and in-vitro drug release study. The optimized microemulsion formulation ME-4 shows more transmittance, drug content, pH of 6.11, less viscous and showed 89.85% cumulative drug release. It was concluded that the microemulsion system studied is a promising tool for the topical delivery and Salicylic acid be formulated as microemulsion with good release and consistency.

Keywords: Salicylic acid, Clove oil, Microemulsion, Pseudoternary phase diagram, Topical delivery.