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Abstract

FORMULATION DEVELOPMENT AND CHARACTERIZATION OF MOUTH DISSOLVING TABLETS OF RABEPRAZOLE CONTAINING SODIUM STARCH GLYCOLATE AS SUPER DISINTEGRANT

Dr. C. Sadak Vali*, Dr. S. Siva Prasad, M. Pradeep Kumar, N. M. Vageesh, Vadduri Swathi and B. Nageswara Naik

Abstract

Rabeprazole is an irreversible proton pump inhibitor and anti-secretory agent, used in the treatment of ulcers and GERD (gastroesophageal reflux disease).[1] Rabeprazole enters the parietal cell and forms covalent bonds with the sulfhydryl amino acids cysteine on the H+/K+ ATP ase pump at the secretory surface and inhibits gastric acid production.[2] The present study aims to develop mouth dissolving tablets of rabeprazole and its evaluation. Further, these formulations were subjected to different evaluation studies like hardness, friability, weight variation, wetting time and dissolution studies. [3] Results for invitro drug release studies suggest that the formulation (F-8) containing sodium starch glycolate as a super disintegrant and HPMC-K4M as a mucoadhesive agent has shown better dissolution properties and mouth dissolving nature within physiological PH range. The present study suggests formulation F-8 which contains HPMC-K4M with sodium starch glycolate in 1:1 shown better hardness and PH compared to other formulations of rabeprazole.

Keywords: Mouth dissolving tablet; proton pump inhibitors; sodium starch glyocolate; GERD.


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