Abstract

EXPLORING “SAMUDRA-FEN”AS AN ALTERNATIVE EXCIPIENT IN THE MANUFACTURING OF FAST DISINTEGRATING TABLET.

A.S. Kulkarni*, S.H. Majumdar, N.H. Aloorkar, K.M. Karande, S. N. Dhayagude

Abstract

Salbutamol Sulphate is a short acting, selective β2 adrenergic receptor agonist widely used as a bronchodilator which is used for the treatment of asthma. The purpose of this research was to explore “samudra-fen” as alternative excipient in the manufacturing of fast disintegrating tablet. Recently fast disintegrating drug delivery system have started gaining popularity and acceptance as a new drug delivery system because they are easy to administer and lead to better patient compliance. In present work an attempt has been made to formulate and evaluate fast disintegrating tablets of Salbutamol Sulphate. Samudra-fen, Croscarmellose sodium, Sodium starch glycolate and crospovidone were used as super disintegrating agents. Direct compression technique was used as it is economical process. The prepared tablets were evaluated for precompressional as well post compressional parameters. Formulations containing combination of 3% Samudra-fen and 3% Crospovidone as super disintegrating agent show rapid disintegrating time as compared to other formulations.

Keywords: Salbutamol Sulphate, Samudra-fen, Croscarmellose sodium, Sodium starch glycolate, crospovidone, Direct compression, Fast disintegrating tablet.