Abstract

REVIEW ON SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM

Pooja K.*, Ganesh N. S. and Vineeth Chandy

Abstract

The Self Nanoemulsifying Drug Delivery System (SNEDDS) could be a Novel Drug Delivery System for solubility of poorly water soluble drug. It’s isotropic mixture that comprises oil, surfactant, cosurfactant molecules and it conjointly containing co-solvent molecule. It’s Drug delivery system is thermodynamically and kinetically stable. The Self Nanoemulsifying Drug Delivery System (SNEDDS) has a very important application on BCS class II and class IV drug, for Solubility of poorly water soluble drug. Following their administration, these systems quickly disperse in GI fluid, yielding micro-/nano-emulsions containing solubilized drug. This results in place solubilisation of drug that may after be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect. This text offers an outline of SEDDS with importance on need of SEDDS, mechanism of SEDDS, varied formulation approaches, ways of formulation of SEDDS and evaluation of SEDDS.

Keywords: Capmul MCM, Span 20, PEG, High-energy emulsification methods.