Abstract

PHTYOCHEMICAL STUDIES AND INVESTIGATION ON THE ANTIINFLAMMATORY ACTIVITY OF Detarium microcarpum GUILL (FABACEAE)

Odoh Uchenna Estella* and Ene Chidiebere

Abstract

This work investigates the anti-inflammatory effect of the methanol leaf extract of Detarium microcarpum Guill (Fabaceae). The antiinflammatory activity of methanol leaf extract of Detarium microcarpum was determined using the egg albumin and formalin induced paw edema method at doses of 200 mg/kg and 400mg/kg. Piroxicam was used as the positive control at a dose of 50 mg/kg. The acute toxicity was carried out using the standard method of Lorke, and the phytochemical test done with the appropriate laboratory procedure. The phytochemical analysis of the extract showed the presence of saponins, tannins, steroids, terpenoids, glycosides, proteins, carbohydrates, flavonoids, reducing sugar, while fats and oil, alkaloids, and resins were absent. Toxicological studies showed that the extract is safe at a dose 5000 mg/kg. The result show that the methanol leaf extract of Detarium microcarpum has significant (P

Keywords: Detarium microcarpum; phytochemical analysis; anti-inflammatory activity, acute toxicity, edema.