Abstract

DESIGN, FABRICATION AND EVALUATION OF DRUG RELEASE KINETICS FROM METFORMIN HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS BY USING NATURAL GUMS

*Raju.Manda, Bonagiri Sreedevi, Virajaji Kaya, Bandla Navya and Dr.R.Suthakaran

Abstract

significant challenges due to its poor inherent compressibility, high dose and high water solubility. Sustained release matrix tablets of Metformin hydrochloride were formulated using different concentration of Guar gum, Xanthan gum, and Chitosan polymers, Drug: Polymer ratio of (3X3+1) 5:1, 5:2, 5:3 and 5:4 by direct compression method. The formulated powder blends were evaluated for angle of repose, bulk density, true density, compressibility index and total % porosity. The tablets were subjected to hardness, friability, % weight variation and % drug content. In vitro release studies were carried out at pH 1.2 and pH 7.2 using the dissolution test apparatus IP/BP/USP. The formulated powder blends and tablets showed satisfactory results from selected formulation. Tablet thus formulated provided Sustained release of Metformin hydrochloride over a period of 10 hrs.

Keywords: Metformin hydrochloride, Guar gum, Xanthangum, and Chitosan, Sustained release Direct compression method.