Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF CEFIXIME USING MUCILAGE OF MIMOSA PUDICA SEED

Magarde Pooja*, Gupta Ashish, Dr. Darwhekar Gajanan

Abstract

The objective of the present investigation was to develop a sustained release tablet of Cefixime by the wet granulation technique using a combination of mucilage of mimosa pudica seed. Different batches of Cefixime sustained release tablets were prepared by using microcrystalline cellulose as disintegrant agent by wet granulation technique. The compatibility of the drug and excipients was done by thin layer chromatography, results were found to be compatible. Granules of prepared batches were evaluated for their physical properties and found to be good and satisfactory. Tablets were evaluated for various physicochemical parameters like hardness (5.33±0.2), thickness (4.7±0.05), friability (4.14±0.9), weight variation test (670±4.47), swelling index (40.79±0.8) in 6 hour, drug content (99.25±0.8), and in-vitro drug release 98.51±0.8 in 12 hour. To study the effect of concentration of mucilage on drug release from SR tablets, 32 full factorial design was applied. The concentration of mucilage and microcrystalline cellulose were used as independent variables, while percentage drug release at 1 h and 12 h were selected as the dependent variable. Formulation F5 was showing the highest sustaining action so this formulation was selected for further study. Drug release of optimized F5 batch was found 98.51% which was found within 12 hours. In order to formulate sustained release tablet, cefixime was mixed with mucilage and other excipient. Drug content in formulation F5 were found to be 99.25% and which sustained the release of drug for 12 hours. Hence it can be concluded that this formulation can be employed to retard the release of drug.

Keywords: Cefixime; Sustained release; Mucilage; Microcrystalline.