Abstract

ANTIFUNGAL SCREENINGOF NITROGEN AND SULPHUR DONOR ATOM CONTAINING LIGAND 3,3’-THIODIPROPIONICACID-BIS(5- AMINO-1,3,4-THIODIAZOLE-2-THIOL) AND ITS Mn(II),Co(II) COMPLEXES: SYNTHESIS, SPECTRSCOPIC APPROCH, MOLECULAR MODELING

Sulekh Chandra*, Seema Gautam, Amit Kumar

Abstract

A novel series ofMn(II)and Co(II)complexes were synthesized by condensation reaction of nitrogen and sulphur donor atom containing ligand 3,3’-thiodipropionicacid-bis (5-amino-1,3,4-thiodiazole-2-thiol) (L) and corresponding metal salt in 1:1 ratio. This multi donor ligand was synthesized by conventional condensation reaction between 3,3’- thiodipropionic acid and 5-amino-1,3,4-thiodiazole-2-thiol in 1:2 ratio. The mode of bonding of ligand toto metal ion and geometry of the synthesized complexes were inferred through elemental analysis, 1HNMR, Mass, IR, molar conductance, magnetic susceptibility, electronic spectra, epr, and molecular modeling. On the basis of above studies, octahedral geometry was assigned for Mn(II) andCo(II) complexes. The in vitroantifungal activityofligand and its Mn(II)and Co(II) complexes was studied. Fungi C.krusei, C.albicans, C.tropicalisand C. parapsilos were takenand well diffusion method was applied to study antifungal activity. A comparative study ofinhibition values indicated that complexes exhibited higher activity than the ligand.

Keywords: 3,3’-thiodipropionic acid; 1H-NMR;electronic spectra; epr; molecular modeling; C. krusei; C. albicans; C. tropicalis; C. parapsilos; well diffusion method.