Abstract

GATRORETENTIVE NANOPARTICLES OF AN ANTI-ASTHMATIC DRUG: DEVELOPMENT AND CHARACTERIZATION

Dr. Umesh Sharma*

Abstract

Introduction: Asthma is one of the most common chronic and noncommunicable diseases in children and adults effecting more than 300 million people worldwide. Intravenous, oral, or inhalation are the common route of drug administration in asthmas. The drugs with high absorption in gastrointestinal tract (GIT) have short half-lives therefore quickly eliminated from the systemic circulation; hence need frequent administration of drug to attain required therapeutic response. Objective: The objective of this research is to develop a novel drug delivery system to prolong gastric retention so that an effective drug concentration can be maintained in the systemic circulation for an extended period of time after oral administration. Method: The nano-precipitation technique was used to formulate nanoparticles so that the toxic effect of chlorinated solvents and surfactants can be eliminated. The hydrophilic polymers like bovine serum albumin, chitosan, and gelatin were used in two drug-polymer ratio (i.e. 1:1 and 2:1) for the preparation of Salbutamol sulphate nanoparticles. The formulated nanoparticles were then evaluated for percentage yield, particle size, surface morphology, drug entrapment efficiency, drug loading efficacy, swelling index, mucoadhesive strength and drug release profile. Results & discussion: The drug and polymer compatibility study shows no major interaction between the drug and polymers. The formulated nanoparticles of Salbutamol with different polymers concentration have shown percentage yield in the range of 72.35± 0.13 % to 86.88± 0.19 %, Drug loading efficacy in the range of 11.19 ± 0.4 % to 31.15 ± 0.8 %, whereas the entrapment efficacy was found in between 54.81±2.9 % and 85.82±4.2 % particle size in the range 287.45±09 nm to 894.06±28nm. Based on results the formulation SNN 2 has been selected as optimised formulation. Conclusion: The formulated Gastro retentive nanoparticles offer many potential advantages like efficient drug delivery; maximizing absorption and enhancing absolute bioavailability with maximum benefit to patient.

Keywords: Nanoparticles, Asthma, Salbutamol, gastroretentive, Anti-asthmatic, nano- precipitation,