Abstract

FORMULATION & EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF METOPROLOL SUCCINATE

K. Venkata Gopaiah*, Dr. P. V. Rao, A. Siva Parvathi, A. Geetha Venkata Lakshmi, D. Hinabindhu, M. Anusha, Dr. CH. Gopala Krishna and B. Mamatha

Abstract

In this study Metoprolol Succinate buccal tablets were prepared and optimized the release of Metoprolol Succinate by using Carbopol, Sodium alginate and Sodium carboxy methyl cellulose as polymers. The tablets prepared by direct compression technique and evaluated by physical parameters and invitro dissolution parameters. A total nine formulations were prepared with varying polymer concentrations. All tablets were acceptable with strength was observed in tablets formulated with Carbopol, sodium alginate and Sodium carboxy methyl cellulose. Formulation F9 showed maximum release 99% in 8 hrs. FT-IR studies showed no evidence of interaction between drug and polymers.

Keywords: Metoprolol Succinate buccal tablets, Carbopol, sodium alginate and Sodium carboxy methyl cellulose.