Abstract

FORMULATION AND CHARATERIZATION OF NANOEMULGEL FOR TRANSDERMAL DRUG DELIVERY

Sushmitha A.* and Parthiban S.

Abstract

The present study focused nanoemulsion-based emulgel for transdermal delivery of Lamivudine. Pseudoternary phase diagram were constructed using titration method to get a nanoemulsion region. Soyabean were oil selected as oily phase, Tween 80 were selected as surfactant and PEG 400 were selected as co surfactant. Nanoemulsion were selected on the basis of compatability studies and emulsification ability. Nanaoemulsion were prepared by spontaneous emulsification method and characterized for percentage transmittance, pH, viscosity, particle size, zeta potential, surface morphology, Invitro-drug release. The optimized nnaoemulsion formulation (NS4) were converted to nanoemulgel by using 2% aloeveragel., and evaluated for pH, viscosity, drug entrapment efficiency, release kinetics and stability studies. The optimized formulation showed 95.36% for 12 hours then release kinetics were fitted with different kinetic model and found that they follow first order kinetics. After the evalution it concluded that Lamivudine nanoemulgel could increase the drug permeability across the membrane, and release of the drug will be fast and can delivered successfully.

Keywords: Lamivudine, Nanoemulgel, Transdermal drug delivery, Pseudoternary phase diagram.