Abstract

REPOSITIONING OF NSAIDS FOR LUNG CANCER TREATMENT AND AUGMENTATION BY QUERCETIN

Archana Moon*, Bhagyashree Fuke, Susmita Patel, C. Shivani Sri, Tejswini Saonerkar, Kanchan Kukreja, Prachi Raut, Ninad Nagarkar and Rita Lakkakul

Abstract

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are widely used analgesics. NSAIDs can inhibit cyclooxygenase (COX) enzyme, thereby targeting the prostaglandin (PG) pathway resulting in the prevention and treatment of cancer. Five NSAIDs were selected belonging to different classes based on the literature survey. The study aims to investigate the cytotoxic effect of NSAIDs and its synergism with quercetin, on lung cancer cell line A549 for repositioning. Cytotoxic assay and in-silico screening of NSAIDs was the methodology employed to attain the objective. The significance of repositioning of NSAIDs is cost-effectiveness and non- invasive cancer management.

Keywords: Repositioning, NSAIDs, Cyclooxygenase enzyme, In-silico Docking, Synergistic effect.